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What is Thrombophilia definition/concept

Thrombophilia is a blood disorder characterized by a tendency to develop venous thrombosis.

It can present with the presence of clots inside the veins of the legs, lungs (pulmonary thromboembolism) and the brain (cerebrovascular accidents). In the case of pregnant women, they may present in the placental veins, in addition to other locations.

Regardless of its location , thrombosis can cause several complications and carry a high risk of mortality, as well as develop sequelae, many of them permanent. Thrombophilia

Manifestations occur in specific situations

It is possible that people with thrombophilia do not know that they are in this condition. In the case of women, they can suffer certain disorders that carry the risk of thrombophilia without knowing it . Only when medical examinations and evaluations are performed for having conditions such as repeated miscarriage or elevated blood pressure. Thrombophilia

Other conditions that manifest the disorder are those in which there is an increased risk of thrombosis, among them are the following:

  • – The post-operative
  • – Prolonged immobilization
  • – Traumas
  • – Autoimmune diseases
  • – Malignant diseases
  • – Use of hormonal contraceptives

It is a condition common to several diseases.

Thrombophilia has several causes. Its hereditary form is related to several types of genetic mutations that affect the molecules that intervene in the regulation of the blood clotting process .

It is also possible that this condition is acquired after birth, as is the case with antiphospholipid syndrome, a disorder of the rheumatic type and of autoimmune origin. Thrombophilia

The various changes that involve this phenomenon cannot be identified by routine laboratory studies. To detect them, special studies that are not normally requested must be carried out, unless there is a case of thrombosis or a history of a direct family member .

Pregnancy is a condition that favors thrombosis

During  pregnancy, a series of hormonal changes occur that favor blood clotting. This entails a large number of complications that can affect its development, triggering situations such as miscarriages, premature birth, changes in the development of the fetus, placental detachment and increased blood pressure by the mother (pre-eclampsia). Thrombophilia

Thrombosis of blood vessels in the placenta causes infarctions, which affect the oxygen supply to the fetus and lead to these complications.

Women with this condition can have a normal  pregnancy and their children are born healthy when correctly diagnosed and treated with anticoagulant medications during  pregnancy. Often this condition must be maintained for up to several weeks after giving birth. Thrombophilia

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